UniProt Protein Function: | G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. |
NCBI Summary: | This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009] |
UniProt Code: | Q86SQ4 |
NCBI GenInfo Identifier: | 215274152 |
NCBI Gene ID: | 57211 |
NCBI Accession: | Q86SQ4.3 |
UniProt Secondary Accession: | Q86SQ4,Q5TGN7, Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8 Q6MZU7, Q8IXA4, Q8NC14, Q96JW0, |
UniProt Related Accession: | Q86SQ4 |
Molecular Weight: | 137kDa |
NCBI Full Name: | Adhesion G-protein coupled receptor G6 |
NCBI Synonym Full Names: | adhesion G protein-coupled receptor G6 |
NCBI Official Symbol: | ADGRG6 |
NCBI Official Synonym Symbols: | APG1; DREG; VIGR; LCCS9; PR126; GPR126; PS1TP2 |
NCBI Protein Information: | adhesion G-protein coupled receptor G6; G-protein coupled receptor 126 |
UniProt Protein Name: | Adhesion G-protein coupled receptor G6 |
UniProt Synonym Protein Names: | Developmentally regulated G-protein-coupled receptor |
Protein Family: | G-protein coupled receptor |
UniProt Gene Name: | ADGRG6 |