GPD1 Antibody (PACO27141)
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주문- SKU:
- PACO27141
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GPD1 Antibody (PACO27141) |
Antibody SKU: | PACO27141 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic protein (1-349AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO27141 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO27141 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Synonyms: | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8), GPD1 |
UniProt Protein Function: | GPD1: Defects in GPD1 are a cause of hypertriglyceridemia, transient infantile (HTGTI). An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.1.1.8; Lipid Metabolism - glycerophospholipid Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: cytosol Molecular Function:glycerol-3-phosphate dehydrogenase (NAD+) activity Biological Process: phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process Disease: Hypertriglyceridemia, Transient Infantile |
NCBI Summary: | This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
UniProt Code: | P21695 |
NCBI GenInfo Identifier: | 134047785 |
NCBI Gene ID: | 2819 |
NCBI Accession: | P21695.4 |
UniProt Secondary Accession: | P21695,Q8N1B0, F8W1L5, |
UniProt Related Accession: | P21695 |
Molecular Weight: | 35,140 Da |
NCBI Full Name: | Glycerol-3-phosphate dehydrogenase |
NCBI Synonym Full Names: | glycerol-3-phosphate dehydrogenase 1 |
NCBI Official Symbol: | GPD1 |
NCBI Official Synonym Symbols: | GPD-C; HTGTI; GPDH-C |
NCBI Protein Information: | glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
UniProt Protein Name: | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
Protein Family: | Glycerol-3-phosphate dehydrogenase |
UniProt Gene Name: | GPD1 |
UniProt Entry Name: | GPDA_HUMAN |