GNL3 Antibody (PACO43615)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO43615
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GNL3 Antibody (PACO43615) |
Antibody SKU: | PACO43615 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Guanine nucleotide-binding protein-like 3 protein (1-240AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human skin tissue using PACO43615 at dilution of 1:100. |
Background: | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. |
Synonyms: | Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin), GNL3, E2IG3 NS |
UniProt Protein Function: | GNL3: May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis. May interact with p53/TP53 via its basic domain. Increased levels in lung tissue in cancer patients. Belongs to the MMR1/HSR1 GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding; Hydrolase; Nucleolus; Cell cycle regulation Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: extracellular space; membrane; nucleolus; nucleus Molecular Function:GTP binding; GTPase activity; protein binding Biological Process: positive regulation of protein sumoylation; positive regulation of telomere maintenance; regulation of cell proliferation; ribosome biogenesis and assembly |
NCBI Summary: | The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q9BVP2 |
NCBI GenInfo Identifier: | 229462872 |
NCBI Gene ID: | 26354 |
NCBI Accession: | Q9BVP2.2 |
UniProt Secondary Accession: | Q9BVP2,Q5PU80, Q96SV6, Q96SV7, Q9UJY0, B2RDC1, |
UniProt Related Accession: | Q9BVP2 |
Molecular Weight: | 60,540 Da |
NCBI Full Name: | Guanine nucleotide-binding protein-like 3 |
NCBI Synonym Full Names: | G protein nucleolar 3 |
NCBI Official Symbol: | GNL3 |
NCBI Official Synonym Symbols: | NS; E2IG3; NNP47; C77032 |
NCBI Protein Information: | guanine nucleotide-binding protein-like 3 |
UniProt Protein Name: | Guanine nucleotide-binding protein-like 3 |
UniProt Synonym Protein Names: | E2-induced gene 3 protein; Novel nucleolar protein 47; NNP47; Nucleolar GTP-binding protein 3; Nucleostemin |
Protein Family: | Guanine nucleotide-binding protein |
UniProt Gene Name: | GNL3 |
UniProt Entry Name: | GNL3_HUMAN |