GNAT1 Antibody (PACO00894)
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주문- SKU:
- PACO00894
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GNAT1 Antibody |
Antibody SKU: | PACO00894 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Galpha t1. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | GNAT1; GNATR; Guanine nucleotide-binding protein G(t) subunit alpha-1; Transducin alpha-1 chain |
UniProt Protein Function: | G-alpha t1: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT1 are the cause of congenital stationary night blindness autosomal dominant type 3 (CSNBAD3); also known as congenital stationary night blindness Nougaret type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. Belongs to the G-alpha family. G(i/o/t/z) subfamily.Protein type: G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G((i/o/t/z))Chromosomal Location of Human Ortholog: 3p21Cellular Component: cytosol; heterotrimeric G-protein complex; membrane; photoreceptor inner segment; photoreceptor outer segment; plasma membraneMolecular Function: acyl binding; G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GDP binding; GTP binding; GTPase activity; protein kinase binding; signal transducer activityBiological Process: detection of light stimulus involved in visual perception; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of cyclic-nucleotide phosphodiesterase activity; phototransduction, visible light; protein folding; regulation of rhodopsin mediated signaling; response to light stimulus; rhodopsin mediated signaling; sensory perception of umami taste; visual perceptionDisease: Night Blindness, Congenital Stationary, Autosomal Dominant 3; Night Blindness, Congenital Stationary, Type 1g |
UniProt Protein Details: | |
NCBI Summary: | Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009] |
UniProt Code: | P11488 |
NCBI GenInfo Identifier: | 121032 |
NCBI Gene ID: | 2779 |
NCBI Accession: | P11488.5 |
UniProt Secondary Accession: | P11488,Q4VBN2 |
UniProt Related Accession: | P11488 |
Molecular Weight: | 40,041 Da |
NCBI Full Name: | Guanine nucleotide-binding protein G(t) subunit alpha-1 |
NCBI Synonym Full Names: | G protein subunit alpha transducin 1 |
NCBI Official Symbol: | GNAT1 |
NCBI Official Synonym Symbols: | GBT1; GNATR; CSNB1G; CSNBAD3 |
NCBI Protein Information: | guanine nucleotide-binding protein G(t) subunit alpha-1 |
UniProt Protein Name: | Guanine nucleotide-binding protein G(t) subunit alpha-1 |
UniProt Synonym Protein Names: | Transducin alpha-1 chain |
Protein Family: | |
UniProt Gene Name: | GNAT1 |
UniProt Entry Name: | GNAT1_HUMAN |