GNAQ Antibody (PACO49642)
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주문- SKU:
- PACO49642
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | GNAQ Antibody (PACO49642) |
Antibody SKU: | PACO49642 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Guanine nucleotide-binding protein G(q) subunit α protein (1-359AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO49642 at dilution of 1:100. |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO49642 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). |
Synonyms: | Guanine nucleotide-binding protein G(q) subunit α (Guanine nucleotide-binding protein alpha-q), GNAQ, GAQ |
UniProt Protein Function: | G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. |
UniProt Protein Details: | Protein type:G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(q) Chromosomal Location of Human Ortholog: 9q21 Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane Molecular Function:GTPase activator activity; GTPase activity; protein binding; type 2A serotonin receptor binding Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; negative regulation of protein kinase activity; phospholipase C activation; phototransduction, visible light; platelet activation; protein stabilization; regulation of action potential Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome |
NCBI Summary: | This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010] |
UniProt Code: | P50148 |
NCBI GenInfo Identifier: | 251757492 |
NCBI Gene ID: | 2776 |
NCBI Accession: | P50148.4 |
UniProt Secondary Accession: | P50148,O15108, Q13462, Q6NT27, Q92471, Q9BZB9, |
UniProt Related Accession: | P50148 |
Molecular Weight: | 42,142 Da |
NCBI Full Name: | Guanine nucleotide-binding protein G(q) subunit alpha |
NCBI Synonym Full Names: | G protein subunit alpha q |
NCBI Official Symbol: | GNAQ |
NCBI Official Synonym Symbols: | GAQ; SWS; CMC1; G-ALPHA-q |
NCBI Protein Information: | guanine nucleotide-binding protein G(q) subunit alpha |
UniProt Protein Name: | Guanine nucleotide-binding protein G(q) subunit alpha |
UniProt Synonym Protein Names: | Guanine nucleotide-binding protein alpha-q |
UniProt Gene Name: | GNAQ |
UniProt Entry Name: | GNAQ_HUMAN |