GNAI3 Antibody (PACO03906)
- SKU:
- PACO03906
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GNAI3 Antibody |
Antibody SKU: | PACO03906 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Galpha i-3. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | GNAI3; Guanine nucleotide-binding protein G(k) subunit alpha; G(i) alpha-3 |
UniProt Protein Function: | G-alpha i3: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily. |
UniProt Protein Details: | Protein type:G protein; G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric Chromosomal Location of Human Ortholog: 1p13 Cellular Component: centrosome; cytoplasm; heterotrimeric G-protein complex; lysosomal membrane; membrane; midbody; plasma membrane Molecular Function:G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GDP binding; GTP binding; GTPase activity; protein binding; signal transducer activity Biological Process: cell division; dopamine receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; GTP metabolic process; negative regulation of adenylate cyclase activity; protein folding Disease: Auriculocondylar Syndrome 1 |
NCBI Summary: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012] |
UniProt Code: | P08754 |
NCBI GenInfo Identifier: | 120996 |
NCBI Gene ID: | 2773 |
NCBI Accession: | P08754.3 |
UniProt Secondary Accession: | P08754,P17539, Q5TZX1, |
UniProt Related Accession: | P08754 |
Molecular Weight: | 40,532 Da |
NCBI Full Name: | Guanine nucleotide-binding protein G(k) subunit alpha |
NCBI Synonym Full Names: | G protein subunit alpha i3 |
NCBI Official Symbol: | GNAI3 |
NCBI Official Synonym Symbols: | 87U6; ARCND1 |
NCBI Protein Information: | guanine nucleotide-binding protein G(k) subunit alpha |
UniProt Protein Name: | Guanine nucleotide-binding protein G(k) subunit alpha |
UniProt Synonym Protein Names: | G(i) alpha-3 |
UniProt Gene Name: | GNAI3 |
UniProt Entry Name: | GNAI3_HUMAN |