GLYCTK Antibody (PACO03457)
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주문- SKU:
- PACO03457
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GLYCTK Antibody |
Antibody SKU: | PACO03457 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Glycerate Kinase. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | GLYCTK; HBEBP4; LP5910; Glycerate kinase; HBeAg-binding protein 4 |
UniProt Protein Function: | GLYCTK: Defects in GLYCTK are the cause of D-glyceric aciduria (D-GA). D-GA is a rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development. Belongs to the glycerate kinase type-2 family. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 2.7.1.31; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - glycine, serine and threonine; Kinase, other Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: cytoplasm; cytosol Molecular Function:glycerate kinase activity; protein binding Biological Process: protein amino acid phosphorylation Disease: D-glyceric Aciduria |
NCBI Summary: | This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] |
UniProt Code: | Q8IVS8 |
NCBI GenInfo Identifier: | 74728080 |
NCBI Gene ID: | 132158 |
NCBI Accession: | Q8IVS8.1 |
UniProt Secondary Accession: | Q8IVS8,Q0P630, Q2EZ43, Q6Y2K6, Q7Z6G5, Q86YR8, Q8TED2 Q8WTY2, |
UniProt Related Accession: | Q8IVS8 |
Molecular Weight: | 22,027 Da |
NCBI Full Name: | Glycerate kinase |
NCBI Synonym Full Names: | glycerate kinase |
NCBI Official Symbol: | GLYCTK |
NCBI Official Synonym Symbols: | HBEBP2; HBEBP4; HBeAgBP4A |
NCBI Protein Information: | glycerate kinase |
UniProt Protein Name: | Glycerate kinase |
UniProt Synonym Protein Names: | HBeAg-binding protein 4 |
UniProt Gene Name: | GLYCTK |
UniProt Entry Name: | GLCTK_HUMAN |