GLRX5 Antibody (PACO59177)
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주문- SKU:
- PACO59177
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GLRX5 Antibody (PACO59177) |
Antibody SKU: | PACO59177 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Glutaredoxin-related protein 5, mitochondrial protein (32-157AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO59177 diluted at 1:500 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO59177 diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity). |
Synonyms: | Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5), GLRX5, C14orf87 |
UniProt Protein Function: | GLRX5: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Belongs to the glutaredoxin family. Monothiol subfamily.Protein type: OxidoreductaseChromosomal Location of Human Ortholog: 14q32.13Cellular Component: mitochondrial matrix; mitochondrionBiological Process: hemopoiesisDisease: Anemia, Sideroblastic, Pyridoxine-refractory, Autosomal Recessive |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010] |
UniProt Code: | Q86SX6 |
NCBI GenInfo Identifier: | 83288163 |
NCBI Gene ID: | 51218 |
NCBI Accession: | Q86SX6.2 |
UniProt Secondary Accession: | Q86SX6,Q0X088, Q3YML0, Q86WY3, Q8IZ54 |
UniProt Related Accession: | Q86SX6 |
Molecular Weight: | 16,628 Da |
NCBI Full Name: | Glutaredoxin-related protein 5, mitochondrial |
NCBI Synonym Full Names: | glutaredoxin 5 |
NCBI Official Symbol: | GLRX5 |
NCBI Official Synonym Symbols: | GRX5; PRSA; SIDBA3; SPAHGC; FLB4739; PR01238; PRO1238; C14orf87 |
NCBI Protein Information: | glutaredoxin-related protein 5, mitochondrial |
UniProt Protein Name: | Glutaredoxin-related protein 5, mitochondrial |
UniProt Synonym Protein Names: | Monothiol glutaredoxin-5 |
Protein Family: | Glutaredoxin-related protein |
UniProt Gene Name: | GLRX5 |
UniProt Entry Name: | GLRX5_HUMAN |