GLRX3 Antibody (PACO43231)
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주문- SKU:
- PACO43231
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GLRX3 Antibody (PACO43231) |
Antibody SKU: | PACO43231 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human, Rat |
Immunogen: | Recombinant Human Glutaredoxin-3 protein (1-335AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: Glutaredoxin-3 antibody at 10µg/ml. Lane 1: Rat brain tissue. Lane 2: HepG2 whole cell lysate. Lane 3: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 37 kDa. Observed band size: 37 kDa. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43231 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43231 at dilution of 1:100. |
Background: | Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. |
Synonyms: | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2), GLRX3, PICOT TXNL2 |
UniProt Protein Function: | GLRX3: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. |
UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 10q26 Cellular Component: cell cortex; Z disc Molecular Function:protein binding; electron carrier activity; protein kinase C binding; metal ion binding; iron-sulfur cluster binding; protein disulfide oxidoreductase activity Biological Process: cell redox homeostasis; regulation of the force of heart contraction |
NCBI Summary: | This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | O76003 |
NCBI GenInfo Identifier: | 37087933 |
NCBI Gene ID: | 10539 |
NCBI Accession: | O76003.2 |
UniProt Related Accession: | O76003 |
Molecular Weight: | Observed: 37 kDaPredicted: 38 kDa |
NCBI Full Name: | Glutaredoxin-3 |
NCBI Synonym Full Names: | glutaredoxin 3 |
NCBI Official Symbol: | GLRX3 |
NCBI Official Synonym Symbols: | GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3 |
NCBI Protein Information: | glutaredoxin-3 |
UniProt Protein Name: | Glutaredoxin-3 |
UniProt Synonym Protein Names: | PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2 |
Protein Family: | Glutaredoxin |
UniProt Gene Name: | GLRX3 |
UniProt Entry Name: | GLRX3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |