GDF9 Antibody (PACO14463)
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주문- SKU:
- PACO14463
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GDF9 Antibody (PACO14463) |
Antibody SKU: | PACO14463 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:500-1:2000, WB:1:100-1:500, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human GDF9 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 12%SDS-PAGE, Lysate: 30 μg, Lane: Human ovarian cancer tissue, Primary antibody: PACO14463(GDF9 Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human stomach cancer tissue using PACO14463(GDF9 Antibody) at dilution 1/7, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-β superfamily. |
Synonyms: | Growth differentiation factor 9 |
UniProt Protein Function: | GDF9: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins. Belongs to the TGF-beta family. |
UniProt Protein Details: | Protein type:Cytokine; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: cytoplasm; extracellular space Molecular Function:cytokine activity; growth factor activity; transforming growth factor beta receptor binding Biological Process: BMP signaling pathway; cell development; female gamete generation; negative regulation of cell growth; oocyte growth; positive regulation of cell proliferation; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the transforming growth factor-beta superfamily. The encoded preproprotein is processed into a secreted factor that is required for ovarian folliculogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
UniProt Code: | O60383 |
NCBI GenInfo Identifier: | 6016124 |
NCBI Gene ID: | 2661 |
NCBI Accession: | O60383.1 |
UniProt Secondary Accession: | O60383,Q4VAW5, |
UniProt Related Accession: | O60383 |
Molecular Weight: | 51,444 Da |
NCBI Full Name: | Growth/differentiation factor 9 |
NCBI Synonym Full Names: | growth differentiation factor 9 |
NCBI Official Symbol: | GDF9 |
NCBI Protein Information: | growth/differentiation factor 9 |
UniProt Protein Name: | Growth/differentiation factor 9 |
Protein Family: | Growth/differentiation factor |
UniProt Gene Name: | GDF9 |
UniProt Entry Name: | GDF9_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |