UniProt Protein Function: | GALNT2: an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. |
UniProt Protein Details: | Protein type:Membrane protein, integral; EC 2.4.1.41; Transferase; Glycan Metabolism - O-glycan biosynthesis Chromosomal Location of Human Ortholog: 1q41-q42 Cellular Component: endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; Golgi stack; membrane; perinuclear region of cytoplasm Molecular Function:manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity; protein binding Biological Process: immunoglobulin biosynthetic process; O-glycan processing; protein amino acid O-linked glycosylation; protein amino acid O-linked glycosylation via serine; protein amino acid O-linked glycosylation via threonine |
NCBI Summary: | This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
UniProt Code: | Q10471 |
NCBI GenInfo Identifier: | 51315838 |
NCBI Gene ID: | 2590 |
NCBI Accession: | Q10471.1 |
UniProt Secondary Accession: | Q10471,Q9NPY4, A8K1Y3, B7Z8V8, C5HU00, |
UniProt Related Accession: | Q10471 |
Molecular Weight: | 30,256 Da |
NCBI Full Name: | Polypeptide N-acetylgalactosaminyltransferase 2 |
NCBI Synonym Full Names: | polypeptide N-acetylgalactosaminyltransferase 2 |
NCBI Official Symbol: | GALNT2 |
NCBI Official Synonym Symbols: | GalNAc-T2 |
NCBI Protein Information: | polypeptide N-acetylgalactosaminyltransferase 2 |
UniProt Protein Name: | Polypeptide N-acetylgalactosaminyltransferase 2 |
UniProt Synonym Protein Names: | Polypeptide GalNAc transferase 2; GalNAc-T2; pp-GaNTase 2 |
Protein Family: | Polypeptide N-acetylgalactosaminyltransferase |
UniProt Gene Name: | GALNT2 |
UniProt Entry Name: | GALT2_HUMAN |