GADD45A Antibody (PACO26889)
- SKU:
- PACO26889
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GADD45A Antibody (PACO26889) |
Antibody SKU: | PACO26889 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Growth arrest and DNA damage-inducible protein GADD45 α protein (1-165AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. |
Synonyms: | Growth arrest and DNA damage-inducible protein GADD45 α (DNA damage-inducible transcript 1 protein) (DDIT-1), GADD45A, DDIT1 GADD45 |
UniProt Protein Function: | GADD45A: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Interacts with MAPK14. Interacts with GADD45GIP1. Interacts with PCNA. By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC. Belongs to the GADD45 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; DNA repair, damage; Apoptosis; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p31.2 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: activation of MAPKKK activity; apoptosis; cell cycle arrest; DNA damage response, signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; positive regulation of apoptosis; positive regulation of JNK cascade; regulation of cyclin-dependent protein kinase activity |
NCBI Summary: | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] |
UniProt Code: | P24522 |
NCBI GenInfo Identifier: | 120751 |
NCBI Gene ID: | 1647 |
NCBI Accession: | P24522.1 |
UniProt Secondary Accession: | P24522,Q5TCA7, Q5TCA8, |
UniProt Related Accession: | P24522 |
Molecular Weight: | 14,622 Da |
NCBI Full Name: | Growth arrest and DNA damage-inducible protein GADD45 alpha |
NCBI Synonym Full Names: | growth arrest and DNA damage inducible alpha |
NCBI Official Symbol: | GADD45A |
NCBI Official Synonym Symbols: | DDIT1; GADD45 |
NCBI Protein Information: | growth arrest and DNA damage-inducible protein GADD45 alpha |
UniProt Protein Name: | Growth arrest and DNA damage-inducible protein GADD45 alpha |
UniProt Synonym Protein Names: | DNA damage-inducible transcript 1 protein; DDIT-1 |
Protein Family: | Growth arrest and DNA damage-inducible protein |
UniProt Gene Name: | GADD45A |
UniProt Entry Name: | GA45A_HUMAN |