UniProt Protein Function: | GADD45A: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Interacts with MAPK14. Interacts with GADD45GIP1. Interacts with PCNA. By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC. Belongs to the GADD45 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; DNA repair, damage; Apoptosis; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p31.2 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: activation of MAPKKK activity; apoptosis; cell cycle arrest; DNA damage response, signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; positive regulation of apoptosis; positive regulation of JNK cascade; regulation of cyclin-dependent protein kinase activity |
NCBI Summary: | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] |
UniProt Code: | P24522 |
NCBI GenInfo Identifier: | 120751 |
NCBI Gene ID: | 1647 |
NCBI Accession: | P24522.1 |
UniProt Secondary Accession: | P24522,Q5TCA7, Q5TCA8, |
UniProt Related Accession: | P24522 |
Molecular Weight: | 14,622 Da |
NCBI Full Name: | Growth arrest and DNA damage-inducible protein GADD45 alpha |
NCBI Synonym Full Names: | growth arrest and DNA damage inducible alpha |
NCBI Official Symbol: | GADD45A |
NCBI Official Synonym Symbols: | DDIT1; GADD45 |
NCBI Protein Information: | growth arrest and DNA damage-inducible protein GADD45 alpha |
UniProt Protein Name: | Growth arrest and DNA damage-inducible protein GADD45 alpha |
UniProt Synonym Protein Names: | DNA damage-inducible transcript 1 protein; DDIT-1 |
Protein Family: | Growth arrest and DNA damage-inducible protein |
UniProt Gene Name: | GADD45A |
UniProt Entry Name: | GA45A_HUMAN |