FUT6 Antibody (PACO43856)
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주문- SKU:
- PACO43856
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FUT6 Antibody (PACO43856) |
Antibody SKU: | PACO43856 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Alpha-(1,3)-fucosyltransferase 6 protein (170-359AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: FUT6 antibody at 4µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 42, 43 kDa Observed band size: 42 kDa |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43856 at dilution of 1:100 |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43856 at dilution of 1:100 |
Background: | Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates. |
Synonyms: | Alpha-(1,3)-fucosyltransferase 6 (EC 2.4.1.65) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase), FUT6, FCT3A |
UniProt Protein Function: | FUT6: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates. Belongs to the glycosyltransferase 10 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transferase; EC 2.4.1.65; Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: Golgi apparatus; integral to membrane Molecular Function:3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; alpha(1,3)-fucosyltransferase activity; fucosyltransferase activity Biological Process: protein amino acid glycosylation; L-fucose catabolic process Disease: Fucosyltransferase 6 Deficiency |
NCBI Summary: | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P51993 |
NCBI GenInfo Identifier: | 1730136 |
NCBI Gene ID: | 2528 |
NCBI Accession: | P51993.1 |
UniProt Related Accession: | P51993 |
Molecular Weight: | Observed Mol.Wt.: 45 kDa. Predicted Mol.Wt.: 42kDa. |
NCBI Full Name: | Alpha-(1,3)-fucosyltransferase 6 |
NCBI Synonym Full Names: | fucosyltransferase 6 |
NCBI Official Symbol: | FUT6 |
NCBI Official Synonym Symbols: | FT1A; FCT3A; Fuc-TVI; FucT-VI |
NCBI Protein Information: | alpha-(1,3)-fucosyltransferase 6 |
UniProt Protein Name: | Alpha-(1,3)-fucosyltransferase 6 |
UniProt Synonym Protein Names: | Fucosyltransferase 6; Fucosyltransferase VI; Fuc-TVI; FucT-VI; Galactoside 3-L-fucosyltransferase |
Protein Family: | Fucosyltransferase |
UniProt Gene Name: | FUT6 |
UniProt Entry Name: | FUT6_HUMAN |