FRK Antibody (PACO44764)
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주문- SKU:
- PACO44764
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FRK Antibody (PACO44764) |
Antibody SKU: | PACO44764 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Tyrosine-protein kinase FRK protein (1-220AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: FRKantibody at 3.13µg/ml. Lane 1: Hela whole cell lysate. Lane 2: 293T whole cell lysate. Lane 3: K562 whole cell lysate. Lane 4: MCF-7 whole cell lysate. Lane 5: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 59, 42 kDa. Observed band size: 59 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO44764 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon tissue using PACO44764 at dilution of 1:100. |
Background: | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
Synonyms: | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5), FRK, PTK5 RAK |
UniProt Protein Function: | FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth. |
UniProt Protein Details: | Protein type:EC 2.7.10.2; Tumor suppressor; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Src family Chromosomal Location of Human Ortholog: 6q21-q22.3 Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; intracellular; intracellular membrane-bound organelle; nucleus Molecular Function:protein binding; receptor binding Biological Process: cell differentiation; innate immune response; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42685 |
NCBI GenInfo Identifier: | 1169745 |
NCBI Gene ID: | 2444 |
NCBI Accession: | P42685.1 |
UniProt Secondary Accession: | P42685,Q13128, Q9NTR5, B4DY49, |
UniProt Related Accession: | P42685 |
Molecular Weight: | 41,980 Da |
NCBI Full Name: | Tyrosine-protein kinase FRK |
NCBI Synonym Full Names: | fyn related Src family tyrosine kinase |
NCBI Official Symbol: | FRK |
NCBI Official Synonym Symbols: | GTK; RAK; PTK5 |
NCBI Protein Information: | tyrosine-protein kinase FRK |
UniProt Protein Name: | Tyrosine-protein kinase FRK |
UniProt Synonym Protein Names: | FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5 |
Protein Family: | Tyrosine-protein kinase |
UniProt Gene Name: | FRK |
UniProt Entry Name: | FRK_HUMAN |
Antibodies | ELISA Kits |
Anti-FRK Antibody (CAB7556) | FRK Colorimetric Cell-Based ELISA |
FRK Antibody (PACO01405) | |
FRK Antibody (PACO09346) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |