FRK Antibody (PACO23741)
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주문- SKU:
- PACO23741
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FRK Antibody (PACO23741) |
Antibody SKU: | PACO23741 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from internal of human FRK. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells, using FRK antibody. | |
Immunofluorescence analysis of HUVEC cells, using FRK antibody. | |
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using FRK antibody. |
Background: | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
Synonyms: | EC 2.7.1.112; EC 2.7.10.2; Nuclear tyrosine protein kinase RAK; Tyrosine-protein kinase FRK; fyn-related kinase |
UniProt Protein Function: | FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth. |
UniProt Protein Details: | Protein type:EC 2.7.10.2; Tumor suppressor; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Src family Chromosomal Location of Human Ortholog: 6q21-q22.3 Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; intracellular; intracellular membrane-bound organelle; nucleus Molecular Function:protein binding; receptor binding Biological Process: cell differentiation; innate immune response; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42685 |
NCBI GenInfo Identifier: | 1169745 |
NCBI Gene ID: | 2444 |
NCBI Accession: | P42685.1 |
UniProt Secondary Accession: | P42685,Q13128, Q9NTR5, B4DY49, |
UniProt Related Accession: | P42685 |
Molecular Weight: | 41,980 Da |
NCBI Full Name: | Tyrosine-protein kinase FRK |
NCBI Synonym Full Names: | fyn related Src family tyrosine kinase |
NCBI Official Symbol: | FRK |
NCBI Official Synonym Symbols: | GTK; RAK; PTK5 |
NCBI Protein Information: | tyrosine-protein kinase FRK |
UniProt Protein Name: | Tyrosine-protein kinase FRK |
UniProt Synonym Protein Names: | FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5 |
Protein Family: | Tyrosine-protein kinase |
UniProt Gene Name: | FRK |
UniProt Entry Name: | FRK_HUMAN |
Antibodies | ELISA Kits |
Anti-FRK Antibody (CAB7556) | FRK Colorimetric Cell-Based ELISA |
FRK Antibody (PACO01405) | |
FRK Antibody (PACO09346) |
Secondary Antibody |
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