FOXD3 Antibody (PACO00818)
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주문- SKU:
- PACO00818
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FOXD3 Antibody |
Antibody SKU: | PACO00818 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | synthesized peptide derived from the Internal region of human FoxD3. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | FOXD3; HFH2; Forkhead box protein D3; HNF3/FH transcription factor genesis |
UniProt Protein Function: | FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: nucleoplasm; nuclear chromatin Molecular Function:protein binding; double-stranded DNA binding; transcription factor activity Biological Process: embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation Disease: Autoimmune Disease, Susceptibility To, 1 |
NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] |
UniProt Code: | Q9UJU5 |
NCBI GenInfo Identifier: | 8134475 |
NCBI Gene ID: | 27022 |
NCBI Accession: | Q9UJU5.1 |
UniProt Secondary Accession: | Q9UJU5,Q9BYM2, Q9UDD1, |
UniProt Related Accession: | Q9UJU5 |
Molecular Weight: | 478 |
NCBI Full Name: | Forkhead box protein D3 |
NCBI Synonym Full Names: | forkhead box D3 |
NCBI Official Symbol: | FOXD3 |
NCBI Official Synonym Symbols: | AIS1; HFH2; VAMAS2; Genesis |
NCBI Protein Information: | forkhead box protein D3; HNF3/FH transcription factor genesis |
UniProt Protein Name: | Forkhead box protein D3 |
UniProt Synonym Protein Names: | HNF3/FH transcription factor genesis |
Protein Family: | Forkhead box protein |
UniProt Gene Name: | FOXD3 |
UniProt Entry Name: | FOXD3_HUMAN |