Flap Endonuclease 1/FEN1 Recombinant Protein (RPES4182)

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SKU:
RPES4182
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Flap Endonuclease 1/FEN1 Recombinant Protein

Flap Endonuclease 1 (FEN1) is a member of the XPG/RAD2 endonuclease family. During DNA replication, FEN1 cleaves the 5'-overhanging flap structure and processes the 5' ends of Okazaki fragments for synthesis. FEN1 also exhibits RNase H activity by possessing 5'-3' exonuclease activity on gapped double-stranded or nicked DNA, FEN1 is involved in the long patch base excision repair (LP-BER) pathway, it can cleave within the apurinic/apyrimidinic (AP) site-terminated flap. FEN1 can prevent flaps from equilibrating into structures that lead to duplications and deletions. FEN1 is also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Product Name:Flap Endonuclease 1/FEN1 Recombinant Protein (RPES4182)
Product Code:RPES4182
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Flap Endonuclease 1, FEN-1, DNase IV, Flap Structure-Specific Endonuclease 1, Maturation Factor 1, MF1, hFEN-1, FEN1, RAD2
Accession:P39748
Sequence:Met 1-Lys380
Fusion tag:
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Flap Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Met1-Lys380 is expressed.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:42.6 kDa
AP Mol Mass:45 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 50 mM Tris, 50mM NaCl, 1mM DDT, 10% Glycerol, pH 8.0.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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