FIS1 Antibody (PACO47418)
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주문- SKU:
- PACO47418
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | FIS1 Antibody (PACO47418) |
Antibody SKU: | PACO47418 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:50-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Mitochondrial fission 1 protein (1-122AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO47418 diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.. |
![]() | Immunofluorescent analysis of Hela cells using PACO47418 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. |
Synonyms: | Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11), FIS1, TTC11 |
UniProt Protein Function: | FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. |
UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to mitochondrial outer membrane; integral to peroxisomal membrane; membrane; mitochondrion; peroxisome; protein complex Molecular Function:protein binding; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; mitochondrion degradation; peroxisome fission; positive regulation of caspase activity; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria |
NCBI Summary: | The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9Y3D6 |
NCBI GenInfo Identifier: | 33112470 |
NCBI Gene ID: | 51024 |
NCBI Accession: | Q9Y3D6.2 |
UniProt Secondary Accession: | Q9Y3D6,Q9BTP3, |
UniProt Related Accession: | Q9Y3D6 |
Molecular Weight: | 16,938 Da |
NCBI Full Name: | Mitochondrial fission 1 protein |
NCBI Synonym Full Names: | fission, mitochondrial 1 |
NCBI Official Symbol: | FIS1 |
NCBI Official Synonym Symbols: | TTC11; CGI-135 |
NCBI Protein Information: | mitochondrial fission 1 protein |
UniProt Protein Name: | Mitochondrial fission 1 protein |
UniProt Synonym Protein Names: | FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11 |
Protein Family: | Mitochondria fission 1 protein |
UniProt Gene Name: | FIS1 |
UniProt Entry Name: | FIS1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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