FHIT Antibody (PACO14430)
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주문- SKU:
- PACO14430
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FHIT Antibody (PACO14430) |
Antibody SKU: | PACO14430 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human FHIT |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 8+12%SDS-PAGE, Lysate: 30 μg, Lane: Human fetal kidney tissue, Primary antibody: PACO14430(FHIT Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14430(FHIT Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. |
Synonyms: | fragile histidine triad |
UniProt Protein Function: | FHIT: a member of the histidine triad gene family. A diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Its gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. A possible tumor suppressor in specific tissues. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. Aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. |
UniProt Protein Details: | Protein type:EC 3.6.1.29; Hydrolase; Motility/polarity/chemotaxis; DNA replication; Nucleotide Metabolism - purine; Tumor suppressor Chromosomal Location of Human Ortholog: 3p14.2 Cellular Component: cytoplasm; cytosol Molecular Function:bis(5'-adenosyl)-triphosphatase activity; catalytic activity; hydrolase activity; identical protein binding; protein binding; ubiquitin protein ligase binding Biological Process: negative regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleotide metabolic process; purine nucleotide metabolic process |
NCBI Summary: | This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | P49789 |
NCBI GenInfo Identifier: | 1706794 |
NCBI Gene ID: | 2272 |
NCBI Accession: | P49789.3 |
UniProt Secondary Accession: | P49789,Q45QG9, Q6IU12, A2IAS9, A2IAT0, A2IAT6, A8K1A9 |
UniProt Related Accession: | P49789 |
Molecular Weight: | 16,858 Da |
NCBI Full Name: | Bis(5'-adenosyl)-triphosphatase |
NCBI Synonym Full Names: | fragile histidine triad |
NCBI Official Symbol: | FHIT |
NCBI Official Synonym Symbols: | FRA3B; AP3Aase |
NCBI Protein Information: | bis(5'-adenosyl)-triphosphatase |
UniProt Protein Name: | Bis(5'-adenosyl)-triphosphatase |
UniProt Synonym Protein Names: | AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein |
Protein Family: | Bis(5'-adenosyl)-triphosphatase |
UniProt Gene Name: | FHIT |
UniProt Entry Name: | FHIT_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |