FGR Antibody (PACO02722)
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주문- SKU:
- PACO02722
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | FGR Antibody |
Antibody SKU: | PACO02722 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from human c-Fgr around the non-phosphorylation site of Y412. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | FGR; SRC2; Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral; v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr |
UniProt Protein Function: | FGR: a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers. |
UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Mitochondrial; Kinase, protein; Oncoprotein; Protein kinase, tyrosine (non-receptor); TK group; Src family Chromosomal Location of Human Ortholog: 1p36.2-p36.1 Cellular Component: actin cytoskeleton; cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; mitochondrial inner membrane; mitochondrial intermembrane space; plasma membrane Molecular Function:ATP binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein kinase binding; protein-tyrosine kinase activity Biological Process: cell differentiation; cell migration; defense response to Gram-positive bacterium; immune response-regulating cell surface receptor signaling pathway; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; response to virus; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | P09769 |
NCBI GenInfo Identifier: | 125358 |
NCBI Gene ID: | 2268 |
NCBI Accession: | P09769.2 |
UniProt Secondary Accession: | P09769,Q9UIQ3, D3DPL7, |
UniProt Related Accession: | P09769 |
Molecular Weight: | 59,479 Da |
NCBI Full Name: | Tyrosine-protein kinase Fgr |
NCBI Synonym Full Names: | FGR proto-oncogene, Src family tyrosine kinase |
NCBI Official Symbol: | FGR |
NCBI Official Synonym Symbols: | SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr |
NCBI Protein Information: | tyrosine-protein kinase Fgr |
UniProt Protein Name: | Tyrosine-protein kinase Fgr |
UniProt Synonym Protein Names: | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr |
Protein Family: | Tyrosine-protein kinase |
UniProt Gene Name: | FGR |
UniProt Entry Name: | FGR_HUMAN |