FGFBP1 Antibody (PACO43506)
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주문- SKU:
- PACO43506
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FGFBP1 Antibody (PACO43506) |
Antibody SKU: | PACO43506 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Fibroblast growth factor-binding protein 1 protein (24-234AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43506 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO43506 at dilution of 1:100. |
Background: | Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. |
Synonyms: | Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (17 kDa heparin-binding growth factor-binding protein) (17 kDa HBGF-binding protein) (HBp17), FGFBP1, FGFBP HBP17 |
UniProt Protein Function: | FGFBP1: Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Belongs to the fibroblast growth factor-binding protein family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4p15.32 Cellular Component: extracellular space; cell surface; plasma membrane Molecular Function:heparin binding; protein binding; fibroblast growth factor binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; positive regulation of cell proliferation; positive regulation of fibroblast growth factor receptor signaling pathway; signal transduction |
NCBI Summary: | This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] |
UniProt Code: | Q14512 |
NCBI GenInfo Identifier: | 74739840 |
NCBI Gene ID: | 9982 |
NCBI Accession: | Q14512.1 |
UniProt Secondary Accession: | Q14512,A8K5J2, |
UniProt Related Accession: | Q14512 |
Molecular Weight: | 234 |
NCBI Full Name: | Fibroblast growth factor-binding protein 1 |
NCBI Synonym Full Names: | fibroblast growth factor binding protein 1 |
NCBI Official Symbol: | FGFBP1 |
NCBI Official Synonym Symbols: | FGFBP; HBP17; FGF-BP; FGF-BP1; FGFBP-1 |
NCBI Protein Information: | fibroblast growth factor-binding protein 1; FGF-binding protein 1; 17 kDa HBGF-binding protein; heparin-binding growth factor binding protein; 17 kDa heparin-binding growth factor-binding protein |
UniProt Protein Name: | Fibroblast growth factor-binding protein 1 |
UniProt Synonym Protein Names: | 17 kDa heparin-binding growth factor-binding protein; 17 kDa HBGF-binding protein; HBp17 |
Protein Family: | Fibroblast growth factor-binding protein |
UniProt Gene Name: | FGFBP1 |
UniProt Entry Name: | FGFP1_HUMAN |
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