FERMT3 Antibody (PACO52498)
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주문- SKU:
- PACO52498
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FERMT3 Antibody (PACO52498) |
Antibody SKU: | PACO52498 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Fermitin family homolog 3 protein (388-503AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO52498 at dilution of 1:100. |
![]() | Immunofluorescent analysis of Hela cells using PACO52498 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). |
Synonyms: | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2), FERMT3, KIND3 MIG2B URP2 |
UniProt Protein Function: | kindlin-3: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3); also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes. Belongs to the kindlin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: membrane; podosome Molecular Function:integrin binding Biological Process: integrin activation; integrin-mediated signaling pathway; leukocyte adhesion; positive regulation of cell migration; regulation of cell-cell adhesion mediated by integrin Disease: Leukocyte Adhesion Deficiency, Type Iii |
NCBI Summary: | Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q86UX7 |
NCBI GenInfo Identifier: | 41018464 |
NCBI Gene ID: | 83706 |
NCBI Accession: | Q86UX7.1 |
UniProt Secondary Accession: | Q86UX7,Q8IUA1, Q8N207, Q9BT48, |
UniProt Related Accession: | Q86UX7 |
Molecular Weight: | 75953 Da |
NCBI Full Name: | Fermitin family homolog 3 |
NCBI Synonym Full Names: | fermitin family member 3 |
NCBI Official Symbol: | FERMT3 |
NCBI Official Synonym Symbols: | URP2; KIND3; MIG-2; MIG2B; URP2SF; UNC112C |
NCBI Protein Information: | fermitin family homolog 3 |
UniProt Protein Name: | Fermitin family homolog 3 |
UniProt Synonym Protein Names: | Kindlin-3; MIG2-like protein; Unc-112-related protein 2 |
Protein Family: | Fermitin family |
UniProt Gene Name: | FERMT3 |
UniProt Entry Name: | URP2_HUMAN |
Antibodies | ELISA Kits |
Anti-FERMT3 Antibody (CAB7839) | Human Fermitin family homolog 3 (FERMT3) ELISA Kit |
FERMT3 Antibody (PACO09277) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |