FCRL3 Antibody (PACO61125)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO61125
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FCRL3 Antibody (PACO61125) |
Antibody SKU: | PACO61125 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Fc receptor-like protein 3 protein (122-222AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO61125 diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Immunofluorescence staining of Hela cells with PACO61125 at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells. |
Synonyms: | Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c), FCRL3, FCRH3 IFGP3 IRTA3 SPAP2 |
UniProt Protein Function: | FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.1 |
NCBI Summary: | This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q96P31 |
NCBI GenInfo Identifier: | 74761021 |
NCBI Gene ID: | 115352 |
NCBI Accession: | Q96P31.1 |
UniProt Secondary Accession: | Q96P31,Q5VXZ8, Q8N6S2, Q96LA4, Q96P27, Q96P28, Q96P29 Q96P30, A0N0M4, A8MTH7, D3DVD2, |
UniProt Related Accession: | Q96P31 |
Molecular Weight: | 81kDa |
NCBI Full Name: | Fc receptor-like protein 3 |
NCBI Synonym Full Names: | Fc receptor like 3 |
NCBI Official Symbol: | FCRL3 |
NCBI Official Synonym Symbols: | FCRH3; IFGP3; IRTA3; SPAP2; CD307c |
NCBI Protein Information: | Fc receptor-like protein 3 |
UniProt Protein Name: | Fc receptor-like protein 3 |
UniProt Synonym Protein Names: | Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c |
Protein Family: | Fc receptor-like protein |
UniProt Gene Name: | FCRL3 |