FBXW7 Antibody (PACO52550)
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주문- SKU:
- PACO52550
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FBXW7 Antibody (PACO52550) |
Antibody SKU: | PACO52550 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry analysis of human kidney tissue using PACO52550 at dilution of 1:100. |
![]() | Immunocytochemistry analysis of human small intestine tissue using PACO52550 at dilution of 1:100. |
Background: | Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. |
Synonyms: | F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4), FBXW7, FBW7 FBX30 SEL10 |
UniProt Code: | Q969H0 |
NCBI GenInfo Identifier: | 44887885 |
NCBI Gene ID: | 55294 |
NCBI Accession: | Q969H0.1 |
UniProt Secondary Accession: | Q969H0,Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6, B7ZLP9 |
UniProt Related Accession: | Q969H0 |
Molecular Weight: | 707 |
NCBI Full Name: | F-box/WD repeat-containing protein 7 |
NCBI Synonym Full Names: | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
NCBI Official Symbol: | FBXW7 |
NCBI Official Synonym Symbols: | AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10 |
NCBI Protein Information: | F-box/WD repeat-containing protein 7; archipelago; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; homolog of C elegans sel-10; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) |
UniProt Protein Name: | F-box/WD repeat-containing protein 7 |
UniProt Synonym Protein Names: | Archipelago homolog; hAgo; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; SEL-10; hCdc4 |
Protein Family: | Cdc42 |
UniProt Gene Name: | FBXW7 |
UniProt Entry Name: | FBXW7_HUMAN |
Antibodies |
Anti-FBXW7 Antibody (CAB5872) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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