EZH1 Antibody (PACO43098)
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주문- SKU:
- PACO43098
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EZH1 Antibody (PACO43098) |
Antibody SKU: | PACO43098 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Histone-lysine N-methyltransferase EZH1 protein (160-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: Histone-lysine N-methyltransferase EZH1 antibody at 4µg/ml. Lane 1: Hela whole cell lysate. Lane 2: HL60 whole cell lysate. Lane 3: Mouse gonad tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 86, 87, 81, 77, 69 kDa. Observed band size: 86 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human lung cancer using PACO43098 at dilution of 1:100. |
Background: | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
Synonyms: | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.43) (ENX-2) (Enhancer of zeste homolog 1), EZH1, KIAA0388 |
UniProt Protein Function: | EZH1: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Belongs to the histone-lysine methyltransferase family. EZ subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Methyltransferase; EC 2.1.1.43; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 17q21.1-q21.3 Cellular Component: nucleoplasm; ESC/E(Z) complex Molecular Function:chromatin binding; histone lysine N-methyltransferase activity (H3-K27 specific) Biological Process: anatomical structure morphogenesis; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009] |
UniProt Code: | Q92800 |
NCBI GenInfo Identifier: | 3334182 |
NCBI Gene ID: | 2145 |
NCBI Accession: | Q92800.2 |
UniProt Secondary Accession: | Q92800,O43287, Q14459, Q53XP3, A6NCH6, B4DIJ1, B4DIZ7 B4DSS2, B4E3R7, |
UniProt Related Accession: | Q92800 |
Molecular Weight: | 747 |
NCBI Full Name: | Histone-lysine N-methyltransferase EZH1 |
NCBI Synonym Full Names: | enhancer of zeste 1 polycomb repressive complex 2 subunit |
NCBI Official Symbol: | EZH1 |
NCBI Official Synonym Symbols: | KMT6B |
NCBI Protein Information: | histone-lysine N-methyltransferase EZH1; ENX-2; enhancer of zeste homolog 1 |
UniProt Protein Name: | Histone-lysine N-methyltransferase EZH1 |
UniProt Synonym Protein Names: | ENX-2; Enhancer of zeste homolog 1 |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | EZH1 |
UniProt Entry Name: | EZH1_HUMAN |
Antibodies |
Anti-EZH1 Antibody (CAB15272) |
Anti-EZH1 Antibody (CAB5818) |
EZH1 Antibody (PACO06461) |
EZH1 Antibody (PACO09179) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |