EXOC2 Antibody (PACO43736)
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주문- SKU:
- PACO43736
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EXOC2 Antibody (PACO43736) |
Antibody SKU: | PACO43736 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Exocyst complex component 2 protein (1-220AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43736 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO43736 at dilution of 1:100. |
Background: | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
Synonyms: | Exocyst complex component 2 (Exocyst complex component Sec5), EXOC2, SEC5 SEC5L1 |
UniProt Protein Function: | Sec5: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 6p25.3 Cellular Component: membrane; intracellular membrane-bound organelle; exocyst; plasma membrane; cytosol Molecular Function:protein binding; Ral GTPase binding; protein N-terminus binding; protein kinase binding Biological Process: Golgi to plasma membrane transport; protein transport; cellular protein metabolic process; exocytosis; organelle organization and biogenesis |
NCBI Summary: | The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q96KP1 |
NCBI GenInfo Identifier: | 15982242 |
NCBI Gene ID: | 55770 |
NCBI Accession: | CAC92092.1 |
UniProt Secondary Accession: | Q96KP1,Q5JPC8, Q96AN6, Q9NUZ8, Q9UJM7, B2RBE6, |
UniProt Related Accession: | Q96KP1 |
Molecular Weight: | 104,066 Da |
NCBI Full Name: | Sec5 protein |
NCBI Synonym Full Names: | exocyst complex component 2 |
NCBI Official Symbol: | EXOC2 |
NCBI Official Synonym Symbols: | SEC5; Sec5p; SEC5L1 |
NCBI Protein Information: | exocyst complex component 2 |
UniProt Protein Name: | Exocyst complex component 2 |
UniProt Synonym Protein Names: | Exocyst complex component Sec5 |
Protein Family: | Exocyst complex component |
UniProt Gene Name: | EXOC2 |
UniProt Entry Name: | EXOC2_HUMAN |