ERP44 Antibody (PACO20798)
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주문- SKU:
- PACO20798
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ERP44 Antibody (PACO20798) |
Antibody SKU: | PACO20798 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human ERP44 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 8%SDS-PAGE,Lysate: 40 µg,Lane 1-7: Raji cells, A549 cells, Hela cells, HepG2 cells, 231 cells, K562 cells, A431 cells,Primary antibody: PACO20798(ERP44 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20798(ERP44 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | ERP44 is a 406 amino acid, protein that contains one thioredoxin domain, a motif that participates in various redox reactions throughout the cell. Localized to the lumen of the endoplasmic reticulum (ER), TXNDC4 functions to inhibit the activity of IP3R-I (inositol 1,4,5-triphosphate receptor,type 1) within calcium channels. In addition, TXNDC4 is thought to regulate oxidative protein folding within the ER and may be involved in retaining proteins. |
Synonyms: | endoplasmic reticulum protein 44 |
UniProt Protein Function: | ERP44: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Endoplasmic reticulum; Secreted; Isomerase Chromosomal Location of Human Ortholog: 9q31.1 Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: glycoprotein metabolic process; protein folding; cell redox homeostasis; response to unfolded protein |
NCBI Summary: | This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016] |
UniProt Code: | Q9BS26 |
NCBI GenInfo Identifier: | 31077035 |
NCBI Gene ID: | 23071 |
NCBI Accession: | Q9BS26.1 |
UniProt Related Accession: | Q9BS26 |
Molecular Weight: | 47kDa |
NCBI Full Name: | Endoplasmic reticulum resident protein 44 |
NCBI Synonym Full Names: | endoplasmic reticulum protein 44 |
NCBI Official Symbol: | ERP44 |
NCBI Official Synonym Symbols: | PDIA10; TXNDC4 |
NCBI Protein Information: | endoplasmic reticulum resident protein 44 |
UniProt Protein Name: | Endoplasmic reticulum resident protein 44 |
UniProt Synonym Protein Names: | Thioredoxin domain-containing protein 4 |
Protein Family: | Endoplasmic reticulum resident protein |
UniProt Gene Name: | ERP44 |
UniProt Entry Name: | ERP44_HUMAN |