EMD Antibody (PACO49558)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO49558
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EMD Antibody (PACO49558) |
Antibody SKU: | PACO49558 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000, |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Emerin protein (1-222AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, Colo320 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, Mouse lung tissue. All lanes: EMD antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 29 kDa. Observed band size: 35 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human bladder cancer using PACO49558 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human heart tissue using PACO49558 at dilution of 1:100. |
Background: | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. |
Synonyms: | Emerin, EMD, EDMD STA |
UniProt Protein Function: | emerin: a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. |
UniProt Protein Details: | Protein type:Cytoskeletal; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: microtubule; nuclear outer membrane; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear inner membrane; nuclear envelope Molecular Function:protein binding; beta-tubulin binding; actin binding Biological Process: positive regulation of protein export from nucleus; mitotic nuclear envelope reassembly; muscle development; muscle contraction; negative regulation of fibroblast proliferation; mitotic nuclear envelope disassembly; mitotic cell cycle Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked |
NCBI Summary: | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50402 |
NCBI GenInfo Identifier: | 1706639 |
NCBI Gene ID: | 2010 |
NCBI Accession: | P50402.1 |
UniProt Secondary Accession: | P50402,Q6FI02, |
UniProt Related Accession: | P50402 |
Molecular Weight: | |
NCBI Full Name: | Emerin |
NCBI Synonym Full Names: | emerin |
NCBI Official Symbol: | EMD |
NCBI Official Synonym Symbols: | STA; EDMD; LEMD5 |
NCBI Protein Information: | emerin; LEM domain containing 5 |
UniProt Protein Name: | Emerin |
Protein Family: | Emerin |
UniProt Gene Name: | EMD |
UniProt Entry Name: | EMD_HUMAN |
Antibodies |
Anti-EMD Antibody (CAB1132) |
Anti-EMD Antibody (CAB13925) |
Anti-EMD Antibody (CAB18016)[KO Validated] |
Anti-EMD Antibody (CAB18030)[KO Validated] |
Anti-Emerin Antibody (CAB4187) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |