EIF3K Antibody (PACO45240)
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주문- SKU:
- PACO45240
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EIF3K Antibody (PACO45240) |
Antibody SKU: | PACO45240 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Eukaryotic translation initiation factor 3 subunit K protein (1-218AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: EIF3K antibody at 1.72µg/ml. Lane 1: THP-1 whole cell lysate. Lane 2: HT29 whole cell lysate. Lane 3: 293T whole cell lysate. Lane 4: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 26, 25 kDa. Observed band size: 26 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45240 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO45240 at dilution of 1:100. |
Background: | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
Synonyms: | Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle-specific gene M9 protein) (PLAC-24) (eIF-3 p25) (eIF-3 p28), EIF3K, EIF3S12 |
UniProt Protein Function: | EIF3K: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Belongs to the eIF-3 subunit K family. |
UniProt Protein Details: | Protein type:Translation initiation; Translation Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 3 complex; membrane Molecular Function:protein binding; translation initiation factor activity Biological Process: translational initiation |
NCBI Summary: | The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9UBQ5 |
NCBI GenInfo Identifier: | 23396628 |
NCBI Gene ID: | 27335 |
NCBI Accession: | Q9UBQ5.1 |
UniProt Secondary Accession: | Q9UBQ5,Q96IQ0, Q9Y6D1, A8K0I9, B7ZAM9, |
UniProt Related Accession: | Q9UBQ5 |
Molecular Weight: | 24,484 Da |
NCBI Full Name: | Eukaryotic translation initiation factor 3 subunit K |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 3 subunit K |
NCBI Official Symbol: | EIF3K |
NCBI Official Synonym Symbols: | M9; ARG134; PLAC24; PTD001; EIF3S12; HSPC029; MSTP001; PLAC-24; PRO1474; EIF3-p28 |
NCBI Protein Information: | eukaryotic translation initiation factor 3 subunit K |
UniProt Protein Name: | Eukaryotic translation initiation factor 3 subunit K |
UniProt Synonym Protein Names: | Eukaryotic translation initiation factor 3 subunit 12 |
UniProt Gene Name: | EIF3K |
UniProt Entry Name: | EIF3K_HUMAN |