EIF2B1 Antibody (PACO44828)
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주문- SKU:
- PACO44828
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EIF2B1 Antibody (PACO44828) |
Antibody SKU: | PACO44828 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Translation initiation factor eIF-2B subunit α protein (1-305AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: EIF2B1 antibody at 5.14µg/ml. Lane 1: K562 whole cell lysate. Lane 2: Mouse brain tissue. Lane 3: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 34, 25 kDa. Observed band size: 34 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO44828 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO44828 at dilution of 1:100. |
Background: | Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. |
Synonyms: | Translation initiation factor eIF-2B subunit α (eIF-2B GDP-GTP exchange factor subunit alpha), EIF2B1, EIF2BA |
UniProt Protein Function: | eIF2B-alpha: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B1 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family. |
UniProt Protein Details: | Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex; membrane; plasma membrane Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity; translation initiation factor activity Biological Process: cellular response to stimulus; methionine salvage; oligodendrocyte development; regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation Disease: Leukoencephalopathy With Vanishing White Matter |
NCBI Summary: | This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q14232 |
NCBI GenInfo Identifier: | 2494303 |
NCBI Gene ID: | 1967 |
NCBI Accession: | Q14232.1 |
UniProt Secondary Accession: | Q14232,Q3SXP4, A6NLY9, B4DGX0, |
UniProt Related Accession: | Q14232 |
Molecular Weight: | 24,618 Da |
NCBI Full Name: | Translation initiation factor eIF-2B subunit alpha |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 2B subunit alpha |
NCBI Official Symbol: | EIF2B1 |
NCBI Official Synonym Symbols: | EIF2B; EIF2BA |
NCBI Protein Information: | translation initiation factor eIF-2B subunit alpha |
UniProt Protein Name: | Translation initiation factor eIF-2B subunit alpha |
UniProt Synonym Protein Names: | eIF-2B GDP-GTP exchange factor subunit alpha |
Protein Family: | Translation initiation factor |
UniProt Gene Name: | EIF2B1 |
UniProt Entry Name: | EI2BA_HUMAN |