EHHADH Antibody (PACO23457)
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주문- SKU:
- PACO23457
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | EHHADH Antibody (PACO23457) |
Antibody SKU: | PACO23457 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human EHHADH. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from A549 cells, using EHHADH antibody. |
![]() | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using EHHADH antibody. |
Background: | The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; ECHD; ECHP |
UniProt Protein Function: | EHHADH: 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; EC 5.3.3.8; Oxidoreductase; EC 4.2.1.17; Other Amino Acids Metabolism - beta-alanine; Lipid Metabolism - fatty acid; EC 1.1.1.35; Mitochondrial; Lyase; Isomerase; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - propanoate Chromosomal Location of Human Ortholog: 3q26.3-q28 Cellular Component: mitochondrion; peroxisome; cytosol Molecular Function:enzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; coenzyme binding; 3-hydroxyacyl-CoA dehydrogenase activity; receptor binding Biological Process: fatty acid beta-oxidation; internal protein amino acid acetylation Disease: Fanconi Renotubular Syndrome 3 |
NCBI Summary: | The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q08426 |
NCBI GenInfo Identifier: | 223590229 |
NCBI Gene ID: | 1962 |
NCBI Accession: | Q08426.3 |
UniProt Secondary Accession: | Q08426,Q58EZ5, A8K6Y3, B4DWG3, D3DNU0, |
UniProt Related Accession: | Q08426 |
Molecular Weight: | 723 |
NCBI Full Name: | Peroxisomal bifunctional enzyme |
NCBI Synonym Full Names: | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase |
NCBI Official Symbol: | EHHADH |
NCBI Official Synonym Symbols: | LBP; ECHD; LBFP; PBFE; FRTS3; L-PBE |
NCBI Protein Information: | peroxisomal bifunctional enzyme; PBE; 3,2-trans-enoyl-CoA isomerase; peroxisomal enoyl-CoA hydratase; L-3-hydroxyacyl-CoA dehydrogenase; L-bifunctional protein, peroxisomal; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase |
UniProt Protein Name: | Peroxisomal bifunctional enzyme |
Protein Family: | Peroxisomal bifunctional enzyme |
UniProt Gene Name: | EHHADH |
UniProt Entry Name: | ECHP_HUMAN |