EHF Antibody (PACO44628)
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주문- SKU:
- PACO44628
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EHF Antibody (PACO44628) |
Antibody SKU: | PACO44628 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human ETS homologous factor protein (1-210AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44628 at dilution of 1:100. |
Background: | Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. |
Synonyms: | ETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3), EHF, ESE3 ESE3B ESEJ |
UniProt Protein Function: | EHF: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 11p12 Cellular Component: nucleoplasm; Golgi apparatus; nucleus Molecular Function:DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; cell proliferation; epithelial cell differentiation; multicellular organismal development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
UniProt Code: | Q9NZC4 |
NCBI GenInfo Identifier: | 74762761 |
NCBI Gene ID: | 26298 |
NCBI Accession: | Q9NZC4.1 |
UniProt Secondary Accession: | Q9NZC4,Q9H509, Q9UKF9, Q9Y5V4, Q9Y5V5, D3DR08, D3DR10 E9PSB2, |
UniProt Related Accession: | Q9NZC4 |
Molecular Weight: | 37,356 Da |
NCBI Full Name: | ETS homologous factor |
NCBI Synonym Full Names: | ets homologous factor |
NCBI Official Symbol: | EHF |
NCBI Official Synonym Symbols: | ESE3; ESEJ; ESE3B |
NCBI Protein Information: | ETS homologous factor; EHF; hEHF; ESE3 transcription factor; ETS domain-containing transcription factor; epithelium-specific Ets transcription factor 3 |
UniProt Protein Name: | ETS homologous factor |
UniProt Synonym Protein Names: | ETS domain-containing transcription factor; Epithelium-specific Ets transcription factor 3; ESE-3 |
Protein Family: | ETS homologous factor |
UniProt Gene Name: | EHF |
UniProt Entry Name: | EHF_HUMAN |