EFHC1 Antibody (PACO45002)
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주문- SKU:
- PACO45002
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EFHC1 Antibody (PACO45002) |
Antibody SKU: | PACO45002 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human EF-hand domain-containing protein 1 protein (391-640AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO45002 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO45002 at dilution of 1:100. |
Background: | Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death. |
Synonyms: | EF-hand domain-containing protein 1 (Myoclonin-1), EFHC1 |
UniProt Protein Function: | EFHC1: microtubule-associated protein (MAP) that is abundant in sperm flagella and motile cilia but expressed at low levels in the adult brain. It is not present in immotile primary cilia. May enhance calcium influx through CACNA1E and stimulate programmed cell death. Interacts with the C-terminus of CACNA1E. Implicated in neuronal migration and may play a role during brain development. Mutations in EFHC1 gene have been previously reported in patients with epilepsies, including those with juvenile myoclonic epilepsy. Two alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6p12.3 Cellular Component: axoneme; cell soma; centrosome Molecular Function:protein binding; protein C-terminus binding Biological Process: cerebral cortex cell migration Disease: Epilepsy, Juvenile Absence, Susceptibility To, 1; Epilepsy, Myoclonic Juvenile |
NCBI Summary: | This gene encodes an EF-hand-containing calcium binding protein. The encoded protein likely plays a role in calcium homeostasis. Mutations in this gene have been associated with susceptibility to juvenile myoclonic epilepsy and juvenile absence epilepsy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q5JVL4 |
NCBI GenInfo Identifier: | 289063386 |
NCBI Gene ID: | 114327 |
NCBI Accession: | NP_001165891.1 |
UniProt Secondary Accession: | Q5JVL4,Q5XKM4, Q6E1U7, Q6E1U8, Q8WUL2, Q9NVW6, B4DMU3 F5GZD8, |
UniProt Related Accession: | Q5JVL4 |
Molecular Weight: | 72,021 Da |
NCBI Full Name: | EF-hand domain-containing protein 1 isoform 2 |
NCBI Synonym Full Names: | EF-hand domain containing 1 |
NCBI Official Symbol: | EFHC1 |
NCBI Official Synonym Symbols: | EJM1; dJ304B14.2 |
NCBI Protein Information: | EF-hand domain-containing protein 1 |
UniProt Protein Name: | EF-hand domain-containing protein 1 |
UniProt Synonym Protein Names: | Myoclonin-1 |
Protein Family: | EF-hand domain-containing protein |
UniProt Gene Name: | EFHC1 |
UniProt Entry Name: | EFHC1_HUMAN |
Antibodies |
Anti-EFHC1 Antibody (CAB8002) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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