EFEMP2 Antibody (PACO23802)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO23802
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EFEMP2 Antibody (PACO23802) |
Antibody SKU: | PACO23802 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human EFEMP2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from K562 cells and 3T3 cells, using EFEMP2 antibody. |
![]() | Immunofluorescence analysis of A549 cells, using EFEMP2 antibody. |
![]() | Immunohistochemistry analysis of paraffin-embedded human placenta tissue using EFEMP2 antibody. |
Background: | A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. |
Synonyms: | EGF-containing fibulin-like extracellular matrix protein 2; FBLN4; |
UniProt Protein Function: | EFEMP2: Defects in EFEMP2 are the cause of cutis laxa, autosomal recessive, type 1B (ARCL1B). A connective tissue disorder characterized by characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. ARCL1B features include emphysema, lethal pulmonary artery occlusion, aortic aneurysm, cardiopulmonary insufficiency, birth fractures, arachnodactyly, and fragility of blood vessels. Belongs to the fibulin family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: basement membrane; extracellular region Molecular Function:extracellular matrix structural constituent; protein binding Disease: Cutis Laxa, Autosomal Recessive, Type Ib |
NCBI Summary: | A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011] |
UniProt Code: | O95967 |
NCBI GenInfo Identifier: | 134047775 |
NCBI Gene ID: | 30008 |
NCBI Accession: | O95967.3 |
UniProt Secondary Accession: | O95967,O75967, A8K7R4, B3KM31, B3KQT1, |
UniProt Related Accession: | O95967 |
Molecular Weight: | 49,405 Da |
NCBI Full Name: | EGF-containing fibulin-like extracellular matrix protein 2 |
NCBI Synonym Full Names: | EGF containing fibulin like extracellular matrix protein 2 |
NCBI Official Symbol: | EFEMP2 |
NCBI Official Synonym Symbols: | MBP1; UPH1; FBLN4; ARCL1B |
NCBI Protein Information: | EGF-containing fibulin-like extracellular matrix protein 2 |
UniProt Protein Name: | EGF-containing fibulin-like extracellular matrix protein 2 |
UniProt Synonym Protein Names: | Fibulin-4; FIBL-4; Protein UPH1 |
Protein Family: | EGF-containing fibulin-like extracellular matrix protein |
UniProt Gene Name: | EFEMP2 |
UniProt Entry Name: | FBLN4_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |