EDNRB Antibody (PACO17821)
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주문- SKU:
- PACO17821
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | EDNRB Antibody (PACO17821) |
Antibody SKU: | PACO17821 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human EDNRB |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17821(EDNRB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17821(EDNRB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | endothelin receptor type B |
UniProt Protein Function: | ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 13q22 Cellular Component: nuclear membrane; integral to plasma membrane; plasma membrane; lipid raft Molecular Function:endothelin receptor activity; protein binding; peptide hormone binding; type 1 angiotensin receptor binding Biological Process: epithelial fluid transport; cGMP-mediated signaling; regulation of fever; negative regulation of cellular protein metabolic process; response to pain; negative regulation of transcription from RNA polymerase II promoter; vein smooth muscle contraction; sensory perception of pain; response to organic cyclic substance; enteric nervous system development; vasodilation; regulation of epithelial cell proliferation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; regulation of blood pressure; melanocyte differentiation; positive regulation of cell proliferation; regulation of pH; neural crest cell migration; aging; posterior midgut development; nervous system development; vasoconstriction; negative regulation of adenylate cyclase activity; macrophage chemotaxis; peripheral nervous system development; negative regulation of neuron maturation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of protein amino acid phosphorylation; regulation of sensory perception of pain; negative regulation of apoptosis Disease: Waardenburg Syndrome, Type 4a; Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2 |
NCBI Summary: | The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
UniProt Code: | P24530 |
NCBI GenInfo Identifier: | 119622 |
NCBI Gene ID: | 1910 |
NCBI Accession: | P24530.1 |
UniProt Secondary Accession: | P24530,O15343, Q59GB1, Q5W0G9, Q8NHM6, Q8NHM7, Q8NHM8 Q8NHM9, Q9UD23, Q9UQK3, A2A2Z8, A8K3T4, |
UniProt Related Accession: | P24530,AAB24922 |
Molecular Weight: | 436 |
NCBI Full Name: | Endothelin B receptor |
NCBI Synonym Full Names: | endothelin receptor type B |
NCBI Official Symbol: | EDNRB |
NCBI Official Synonym Symbols: | ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2 |
NCBI Protein Information: | endothelin B receptor; endothelin receptor non-selective type |
UniProt Protein Name: | Endothelin B receptor |
UniProt Synonym Protein Names: | Endothelin receptor non-selective type |
Protein Family: | Endothelin B receptor |
UniProt Gene Name: | EDNRB |
UniProt Entry Name: | EDNRB_HUMAN |
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