ECE2 Antibody (PACO14360)
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주문- SKU:
- PACO14360
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ECE2 Antibody (PACO14360) |
Antibody SKU: | PACO14360 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human ECE2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO14360(ECE2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14360(ECE2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Endothelin-converting enzymes, such as ECE2 (EC 3.4.24.71), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family. It converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity. |
Synonyms: | endothelin converting enzyme 2 |
UniProt Protein Function: | ECE2: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.24.71; Methyltransferase, protein arginine, predicted; Vesicle; Methyltransferase; Protease; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: cytoplasmic vesicle membrane Molecular Function:metalloendopeptidase activity; protein binding Biological Process: brain development; cardioblast differentiation; cell-cell signaling; heart development; peptide hormone processing |
NCBI Summary: | This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
UniProt Code: | O60344 |
NCBI GenInfo Identifier: | 215274248 |
NCBI Gene ID: | 9718 |
NCBI Accession: | O60344.4 |
UniProt Secondary Accession: | O60344,Q6NTG7, Q6UW36, Q8NFD7, Q96NX3, Q96NX4, Q9BRZ8 A5PLK8, |
UniProt Related Accession: | O60344 |
Molecular Weight: | 91,211 Da |
NCBI Full Name: | Endothelin-converting enzyme 2 |
NCBI Synonym Full Names: | endothelin converting enzyme 2 |
NCBI Official Symbol: | ECE2 |
NCBI Protein Information: | endothelin-converting enzyme 2 |
UniProt Protein Name: | Endothelin-converting enzyme 2 |
Protein Family: | Endothelin-converting enzyme |
UniProt Gene Name: | ECE2 |
UniProt Entry Name: | ECE2_HUMAN |
Antibodies |
Anti-ECE2 Antibody (CAB7049) |
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