ECE1 Antibody (PACO14361)
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주문- SKU:
- PACO14361
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ECE1 Antibody (PACO14361) |
Antibody SKU: | PACO14361 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:1000-1:5000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human ECE1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane: Mouse heart tissue, Primary antibody: PACO14361(ECE1 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
Background: | The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
Synonyms: | endothelin converting enzyme 1 |
UniProt Protein Function: | ECE1: Converts big endothelin-1 to endothelin-1. Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. Belongs to the peptidase M13 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; Membrane protein, integral; Vesicle; Cell surface; EC 3.4.24.71 Chromosomal Location of Human Ortholog: 1p36.1 Cellular Component: membrane; lysosomal membrane; perinuclear region of cytoplasm; early endosome; plasma membrane; integral to membrane; endosome; vesicle; external side of plasma membrane Molecular Function:protein homodimerization activity; peptide hormone binding; metalloendopeptidase activity; metal ion binding; endopeptidase activity Biological Process: pharyngeal system development; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction; heart development; peptide hormone processing; ear development; hormone catabolic process; protein processing; embryonic digit morphogenesis; proteolysis; positive regulation of receptor recycling Disease: Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction; Hypertension, Essential |
NCBI Summary: | The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009] |
UniProt Code: | P42892 |
NCBI GenInfo Identifier: | 1706563 |
NCBI Gene ID: | 1889 |
NCBI Accession: | P42892.2 |
UniProt Secondary Accession: | P42892,Q14217, Q17RN5, Q2Z2K8, Q58GE7, Q5THM5, Q5THM7 Q5THM8, Q9UJQ6, Q9UPF4, A8K3P1, B4E291, |
UniProt Related Accession: | P42892 |
Molecular Weight: | 87,022 Da |
NCBI Full Name: | Endothelin-converting enzyme 1 |
NCBI Synonym Full Names: | endothelin converting enzyme 1 |
NCBI Official Symbol: | ECE1 |
NCBI Official Synonym Symbols: | ECE |
NCBI Protein Information: | endothelin-converting enzyme 1; ECE-1 |
UniProt Protein Name: | Endothelin-converting enzyme 1 |
Protein Family: | Endothelin-converting enzyme |
UniProt Gene Name: | ECE1 |
UniProt Entry Name: | ECE1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |