E2F2 Antibody (PACO35766)
- SKU:
- PACO35766
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | E2F2 Antibody (PACO35766) |
Antibody SKU: | PACO35766 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Transcription factor E2F2 protein (1-83AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: E2F2 antibody at 2µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48 kDa. Observed band size: 48 kDa. | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO35766 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO35766 at dilution of 1:100. |
Background: | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. |
Synonyms: | Transcription factor E2F2 (E2F-2), E2F2 |
UniProt Protein Function: | E2F2: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p36 Cellular Component: nucleoplasm; transcription factor complex Molecular Function:protein binding; DNA binding; transcription factor binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle |
NCBI Summary: | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14209 |
NCBI GenInfo Identifier: | 2494228 |
NCBI Gene ID: | 1870 |
NCBI Accession: | Q14209.1 |
UniProt Secondary Accession: | Q14209,Q7Z6H1, B2R9W1, |
UniProt Related Accession: | Q14209 |
Molecular Weight: | 47,506 Da |
NCBI Full Name: | Transcription factor E2F2 |
NCBI Synonym Full Names: | E2F transcription factor 2 |
NCBI Official Symbol: | E2F2 |
NCBI Official Synonym Symbols: | E2F-2 |
NCBI Protein Information: | transcription factor E2F2 |
UniProt Protein Name: | Transcription factor E2F2 |
Protein Family: | Transcription factor |
UniProt Gene Name: | E2F2 |
UniProt Entry Name: | E2F2_HUMAN |