DYNC2H1 Antibody (PACO50782)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO50782
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | DYNC2H1 Antibody (PACO50782) |
Antibody SKU: | PACO50782 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cytoplasmic dynein 2 heavy chain 1 protein (1928-2065AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO50782 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO50782 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO50782 at dilution of 1:100. |
Background: | May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). |
Synonyms: | Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B), DYNC2H1, DHC1B DHC2 DNCH2 DYH1B KIAA1997 |
UniProt Protein Function: | DYNC2H1: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells. Defects in DYNC2H1 are the cause of asphyxiating thoracic dystrophy type 3 (ATD3). ATD3 is an autosomal recessive osteochondrodysplasia which often leads to death in infancy because of a severely constricted thoracic cage and respiratory insufficiency. Defects in DYNC2H1 are the cause of short rib-polydactyly syndrome type 3 (SRPS3); also called Verma-Naumoff syndrome. A lethal skeletal dysplasia characterized by markedly short ribs, short limbs, polydactyly, narrow thorax, and multiple anomalies of major organs, including heart, intestines, genitalia, kidney, liver, and pancreas. Belongs to the dynein heavy chain family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q21-q22.1 Cellular Component: dynein complex; Golgi apparatus; microtubule; apical part of cell; plasma membrane; motile primary cilium; axoneme; cytosol Molecular Function:ATPase activity; motor activity; microtubule motor activity; ATP binding Biological Process: asymmetric protein localization; dorsal/ventral pattern formation; organelle organization and biogenesis; forebrain development; positive regulation of smoothened signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; cilium biogenesis; protein processing; determination of left/right symmetry; spinal cord motor neuron differentiation; Golgi organization and biogenesis; embryonic limb morphogenesis Disease: Short-rib Thoracic Dysplasia 3 With Or Without Polydactyly |
NCBI Summary: | This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q8NCM8 |
NCBI GenInfo Identifier: | 283806679 |
NCBI Gene ID: | 79659 |
NCBI Accession: | NP_001368.2 |
UniProt Secondary Accession: | Q8NCM8,O00432, Q16693, Q3C1U8, Q4AC93, Q6ZMX7, Q6ZUM6 Q7Z363, Q8N977, Q92815, Q9HAE4, |
UniProt Related Accession: | Q8NCM8 |
Molecular Weight: | 105,369 Da |
NCBI Full Name: | cytoplasmic dynein 2 heavy chain 1 isoform 1 |
NCBI Synonym Full Names: | dynein, cytoplasmic 2, heavy chain 1 |
NCBI Official Symbol: | DYNC2H1 |
NCBI Official Synonym Symbols: | ATD3; DHC2; DHC1b; DNCH2; DYH1B; SRTD3; SRPS2B; hdhc11 |
NCBI Protein Information: | cytoplasmic dynein 2 heavy chain 1; dynein heavy chain 11; dynein heavy chain isotype 1B; dynein heavy chain, isotype 1B; dynein cytoplasmic heavy chain 2; dynein, cytoplasmic, heavy polypeptide 2 |
UniProt Protein Name: | Cytoplasmic dynein 2 heavy chain 1 |
UniProt Synonym Protein Names: | Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain 11; hDHC11; Dynein heavy chain isotype 1B |
UniProt Gene Name: | DYNC2H1 |
UniProt Entry Name: | DYHC2_HUMAN |
Antibodies |
Anti-DYNC2H1 Antibody (CAB13126) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |