DVL3 Antibody (PACO56098)
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주문- SKU:
- PACO56098
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DVL3 Antibody (PACO56098) |
Antibody SKU: | PACO56098 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Segment polarity protein dishevelled homolog DVL-3 protein (509-696AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO56098 diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
Immunofluorescence staining of Hela cells with PACO56098 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
Synonyms: | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3), DVL3, KIAA0208 |
UniProt Protein Function: | DVL3: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3q27 Cellular Component: cytosol Molecular Function:protein binding; protease binding; frizzled binding; protein heterodimerization activity; beta-catenin binding; receptor binding Biological Process: response to drug; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin |
NCBI Summary: | This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92997 |
NCBI GenInfo Identifier: | 6919875 |
NCBI Gene ID: | 1857 |
NCBI Accession: | Q92997.2 |
UniProt Secondary Accession: | Q92997,O14642, Q13531, Q8N5E9, Q92607, B4E3E5, D3DNT0 |
UniProt Related Accession: | Q92997 |
Molecular Weight: | 716 |
NCBI Full Name: | Segment polarity protein dishevelled homolog DVL-3 |
NCBI Synonym Full Names: | dishevelled segment polarity protein 3 |
NCBI Official Symbol: | DVL3 |
NCBI Protein Information: | segment polarity protein dishevelled homolog DVL-3; DSH homolog 3; dishevelled-3; dishevelled, dsh homolog 3; dishevelled 3 (homologous to Drosophila dsh) |
UniProt Protein Name: | Segment polarity protein dishevelled homolog DVL-3 |
UniProt Synonym Protein Names: | DSH homolog 3 |
Protein Family: | Segment polarity protein dishevelled |
UniProt Gene Name: | DVL3 |
UniProt Entry Name: | DVL3_HUMAN |