DUSP5 Antibody (PACO61378)
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주문- SKU:
- PACO61378
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DUSP5 Antibody (PACO61378) |
Antibody SKU: | PACO61378 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dual specificity protein phosphatase 5 protein (56-181AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of A549 cells with PACO61378 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. |
Synonyms: | Dual specificity protein phosphatase 5, Dual specificity protein phosphatase hVH3, DUSP5, VH3 |
UniProt Protein Function: | Function: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1. |
UniProt Protein Details: | Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.A phosphoprotein + H2O = a protein + phosphate. Subcellular location: Nucleus Potential. Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Contains 1 rhodanese domain.Contains 1 tyrosine-protein phosphatase domain. |
NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16690 |
NCBI GenInfo Identifier: | 62865890 |
NCBI Gene ID: | 1847 |
NCBI Accession: | NP_004410 |
UniProt Related Accession: | Q16690 |
Molecular Weight: | 42kDa |
NCBI Full Name: | dual specificity protein phosphatase 5 |
NCBI Synonym Full Names: | dual specificity phosphatase 5 |
NCBI Official Symbol: | DUSP5 |
NCBI Official Synonym Symbols: | DUSP; HVH3 |
NCBI Protein Information: | dual specificity protein phosphatase 5 |
UniProt Protein Name: | Dual specificity protein phosphatase 5 |
UniProt Synonym Protein Names: | Dual specificity protein phosphatase hVH3 |
Protein Family: | Dual specificity protein phosphatase |
UniProt Gene Name: | DUSP5 |
UniProt Entry Name: | DUS5_HUMAN |
Antibodies | ELISA Kits |
Anti-DUSP5 Antibody (CAB10212) | Human DUSP5 / VH3 ELISA Kit |
Human Dual specificity protein phosphatase 5 (DUSP5) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |