DTX2 Antibody (PACO14336)
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주문- SKU:
- PACO14336
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DTX2 Antibody (PACO14336) |
Antibody SKU: | PACO14336 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human DTX2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14336(DTX2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
Synonyms: | deltex 2, E3 ubiquitin ligase |
UniProt Protein Function: | DTX2: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: nucleoplasm; nuclear membrane; cytoplasm Molecular Function:protein binding; zinc ion binding; ligase activity Biological Process: Notch signaling pathway; protein ubiquitination |
NCBI Summary: | DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] |
UniProt Code: | Q86UW9 |
NCBI GenInfo Identifier: | 68067880 |
NCBI Gene ID: | 113878 |
NCBI Accession: | Q86UW9.3 |
UniProt Related Accession: | Q86UW9 |
Molecular Weight: | Observed: 67 kDaPredicted: 68 kDa |
NCBI Full Name: | Probable E3 ubiquitin-protein ligase DTX2 |
NCBI Synonym Full Names: | deltex E3 ubiquitin ligase 2 |
NCBI Official Symbol: | DTX2 |
NCBI Official Synonym Symbols: | RNF58 |
NCBI Protein Information: | probable E3 ubiquitin-protein ligase DTX2 |
UniProt Protein Name: | Probable E3 ubiquitin-protein ligase DTX2 |
UniProt Synonym Protein Names: | Protein deltex-2; Deltex2; hDTX2; RING finger protein 58 |
Protein Family: | Protein DETOXIFICATION |
UniProt Gene Name: | DTX2 |
UniProt Entry Name: | DTX2_HUMAN |