DSC2 Antibody (PACO45386)
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주문- SKU:
- PACO45386
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DSC2 Antibody (PACO45386) |
Antibody SKU: | PACO45386 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Desmocollin-2 protein (520-690AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO45386 at dilution of 1:100. |
Background: | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
Synonyms: | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III), DSC2, CDHF2 DSC3 |
UniProt Protein Function: | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
NCBI Summary: | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
UniProt Code: | Q02487 |
NCBI GenInfo Identifier: | 461968 |
NCBI Gene ID: | 1824 |
NCBI Accession: | Q02487.1 |
UniProt Related Accession: | Q02487 |
Molecular Weight: | 100kDa |
NCBI Full Name: | Desmocollin-2 |
NCBI Synonym Full Names: | desmocollin 2 |
NCBI Official Symbol: | DSC2 |
NCBI Official Synonym Symbols: | DG2; DSC3; CDHF2; ARVD11; DGII/III |
NCBI Protein Information: | desmocollin-2 |
UniProt Protein Name: | Desmocollin-2 |
UniProt Synonym Protein Names: | Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III |
Protein Family: | Desmocollin |
UniProt Gene Name: | DSC2 |
Antibodies |
Anti-DSC2 Antibody (CAB10211) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |