DRD4 Antibody (PACO17774)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO17774
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | DRD4 Antibody (PACO17774) |
Antibody SKU: | PACO17774 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:500-1:5000, WB:1:500-1:1000, IHC:1:5-1:20 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human DRD4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse skeletal muscle tissue, Primary antibody: PACO17774(DRD4 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17774(DRD4 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. |
Synonyms: | Dopamine receptor D4 |
UniProt Protein Function: | DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; protein binding; SH3 domain binding Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; response to amphetamine; synaptic transmission, dopaminergic Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait |
NCBI Summary: | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008] |
UniProt Code: | P21917 |
NCBI GenInfo Identifier: | 1345939 |
NCBI Gene ID: | 1815 |
NCBI Accession: | P21917.2 |
UniProt Secondary Accession: | P21917,Q7Z7Q5, Q8NGM5, B0M0J7, |
UniProt Related Accession: | P21917 |
Molecular Weight: | 48,361 Da |
NCBI Full Name: | D(4) dopamine receptor |
NCBI Synonym Full Names: | dopamine receptor D4 |
NCBI Official Symbol: | DRD4 |
NCBI Official Synonym Symbols: | D4DR |
NCBI Protein Information: | D(4) dopamine receptor |
UniProt Protein Name: | D(4) dopamine receptor |
UniProt Synonym Protein Names: | D(2C) dopamine receptor; Dopamine D4 receptor |
Protein Family: | D(4) dopamine receptor |
UniProt Gene Name: | DRD4 |
UniProt Entry Name: | DRD4_HUMAN |
Antibodies | ELISA Kits |
Anti-DRD4 Antibody (CAB1337) | Human D4R/DRD4 (Dopamine Receptor D4) ELISA Kit (HUES02295) |
Anti-DRD4 Antibody (CAB2894) | |
DRD4 Antibody (PACO06418) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |