DPYS Antibody (PACO44259)
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주문- SKU:
- PACO44259
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DPYS Antibody (PACO44259) |
Antibody SKU: | PACO44259 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Dihydropyrimidinase protein (250-519AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: DPYS antibody at 1.1µg/ml. Lane 1: Mouse liver tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 57 kDa. Observed band size: 57 kDa.. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO44259 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44259 at dilution of 1:100. |
Background: | Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. |
Synonyms: | Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase), DPYS |
UniProt Protein Function: | DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. |
UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase; EC 3.5.2.2; Other Amino Acids Metabolism - beta-alanine; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis Chromosomal Location of Human Ortholog: 8q22 Cellular Component: cytosol Molecular Function:dihydropyrimidinase activity Biological Process: protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process Disease: Dihydropyrimidinase Deficiency |
NCBI Summary: | Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14117 |
NCBI GenInfo Identifier: | 3122049 |
NCBI Gene ID: | 1807 |
NCBI Accession: | Q14117.1 |
UniProt Related Accession: | Q14117 |
Molecular Weight: | 56,630 Da |
NCBI Full Name: | Dihydropyrimidinase |
NCBI Synonym Full Names: | dihydropyrimidinase |
NCBI Official Symbol: | DPYS |
NCBI Official Synonym Symbols: | DHP; DHPase |
NCBI Protein Information: | dihydropyrimidinase |
UniProt Protein Name: | Dihydropyrimidinase |
UniProt Synonym Protein Names: | Dihydropyrimidine amidohydrolase; Hydantoinase |
UniProt Gene Name: | DPYS |
UniProt Entry Name: | DPYS_HUMAN |