Dog IL 3 Recombinant Protein (RPPB0501)

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SKU:
RPPB0501
Product type:
Recombinant Protein
Size:
10ug
Species:
Dog
Target:
IL 3
Synonyms:
MCGF (Mast cell growth factor)
Synonyms:
Multi-CSF
Synonyms:
HCGF
Synonyms:
P-cell stimulation factor
Source:
Escherichia Coli
Uniprot:
Q9BDX4
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Description

Product Name:Dog IL 3 Recombinant Protein
Product Code:RPPB0501
Size:10µg
Species:Dog
Target:IL 3
Synonyms:MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor, IL-3, MGC79398, MGC79399.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a concentrated (1mg/ml) solution in water containing 1X PBS pH7.4.
Solubility:It is recommended to reconstitute the lyophilized IL3 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IL3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL3 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by HPLC. (b) Analysis by SDS-PAGE.
Amino Acid Sequence:RPFSTDLPKQ YFTMINEIME MLNKSPSPSE EPLDSNEKET LLEDTLLRPN LDVFLNASSK FHKNGLLIWN NLKEFLPLLP TPTPRGEPIS IMENNWGDFQ RKLKKYLEAL DNFLNFKNKP
Biological Activity:The ED50 as determined by the dose-dependant stimulation of TF-1 cells is < 0.2 ng/ml, corresponding to a Specific Activity of 5,000,000 IU/mg.

IL3 is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

Interleukin-3 Canine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids and having a molecular mass of 14 kDa.The IL-3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophagesBy similarity.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytesSubunit structure: MonomerSubcellular location: Secreted.Sequence similarities: Belongs to the IL-3 family.
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9BDX4
NCBI GenInfo Identifier:62078415
NCBI Gene ID:481497
NCBI Accession:NP_001013857.1
UniProt Secondary Accession:Q9BDX4
UniProt Related Accession:Q9BDX4
Molecular Weight:16,499 Da
NCBI Full Name:interleukin-3
NCBI Synonym Full Names:
NCBI Official Symbol:IL3  
NCBI Official Synonym Symbols:IL-3; MCGF  
NCBI Protein Information:interleukin-3; mast cell growth factor; P-cell-stimulating factor; hematopoietic growth factor; multipotential colony-stimulating factor
UniProt Protein Name:Interleukin-3
UniProt Synonym Protein Names:Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
Protein Family:Interleukin
UniProt Gene Name:IL3  
UniProt Entry Name:IL3_CANFA
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