DND1 Antibody (PACO62519)
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주문- SKU:
- PACO62519
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DND1 Antibody (PACO62519) |
Antibody SKU: | PACO62519 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dead end protein homolog 1 protein (37-180AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of Hela cells with PACO62519 at 1:233, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). |
Synonyms: | Dead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4), DND1, RBMS4 |
UniProt Protein Function: | DND1: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: cytoplasm; nucleus Molecular Function:AU-rich element binding; miRNA binding |
NCBI Summary: | This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q8IYX4 |
NCBI GenInfo Identifier: | 60389799 |
NCBI Gene ID: | 373863 |
NCBI Accession: | Q8IYX4.1 |
UniProt Related Accession: | Q8IYX4 |
Molecular Weight: | 38,687 Da |
NCBI Full Name: | Dead end protein homolog 1 |
NCBI Synonym Full Names: | DND microRNA-mediated repression inhibitor 1 |
NCBI Official Symbol: | DND1 |
NCBI Official Synonym Symbols: | RBMS4 |
NCBI Protein Information: | dead end protein homolog 1 |
UniProt Protein Name: | Dead end protein homolog 1 |
UniProt Synonym Protein Names: | RNA-binding motif, single-stranded-interacting protein 4 |
Protein Family: | Dead end protein |
UniProt Gene Name: | DND1 |
UniProt Entry Name: | DND1_HUMAN |
Antibodies |
Anti-DND1 Antibody (CAB18567) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |