DMGDH Antibody (PACO22305)
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주문- SKU:
- PACO22305
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DMGDH Antibody (PACO22305) |
Antibody SKU: | PACO22305 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from C-terminal of human DMGDH. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from HT-29 cells and A549 cells, using DMGDH antibody. |
Background: | This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. |
Synonyms: | dimethylglycine dehydrogenase; mitochondrial; EC 1.5.99.2; M2GD; ME2GLYDH |
UniProt Protein Function: | DMGDH: Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD). DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N- dimethylglycine (DMG) in serum and urine. Belongs to the GcvT family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - glycine, serine and threonine; EC 1.5.8.4; Mitochondrial; Oxidoreductase Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: mitochondrial matrix Molecular Function:dimethylglycine dehydrogenase activity; electron carrier activity Biological Process: betaine catabolic process; choline metabolic process; glycine metabolic process Disease: Dimethylglycine Dehydrogenase Deficiency |
NCBI Summary: | This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9UI17 |
NCBI GenInfo Identifier: | 296434575 |
NCBI Gene ID: | 29958 |
NCBI Accession: | Q9UI17.2 |
UniProt Secondary Accession: | Q9UI17,B2RBN0, B4E1J9, |
UniProt Related Accession: | Q9UI17 |
Molecular Weight: | 45,079 Da |
NCBI Full Name: | Dimethylglycine dehydrogenase, mitochondrial |
NCBI Synonym Full Names: | dimethylglycine dehydrogenase |
NCBI Official Symbol: | DMGDH |
NCBI Official Synonym Symbols: | DMGDHD; ME2GLYDH |
NCBI Protein Information: | dimethylglycine dehydrogenase, mitochondrial |
UniProt Protein Name: | Dimethylglycine dehydrogenase, mitochondrial |
UniProt Synonym Protein Names: | ME2GLYDH |
Protein Family: | Dimethylglycine dehydrogenase |
UniProt Gene Name: | DMGDH |
UniProt Entry Name: | M2GD_HUMAN |
Antibodies | ELISA Kits |
DMGDH Antibody (PACO00712) | Human DMGDH / Dimethylglycine dehydrogenase ELISA Kit |
Human Dimethylglycine dehydrogenase, mitochondrial (DMGDH) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |