DLX5 Antibody (PACO45766)
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주문- SKU:
- PACO45766
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DLX5 Antibody (PACO45766) |
Antibody SKU: | PACO45766 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Homeobox protein DLX-5 protein (1-249AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO45766 at dilution of 1:100. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO45766 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. |
Synonyms: | Homeobox protein DLX-5, DLX5 |
UniProt Protein Function: | DLX5: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Defects in DLX5 are the cause of split-hand/foot malformation type 1, with sensorineural hearing loss (SHFM1D). A disease characterized by the association of split- hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Belongs to the distal-less homeobox family. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 7q22 Cellular Component: nuclear chromatin Biological Process: BMP signaling pathway; cell proliferation; endochondral ossification; nervous system development; osteoblast differentiation; positive regulation of transcription, DNA-dependent; skeletal development Disease: Split-hand/foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive |
NCBI Summary: | This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008] |
UniProt Code: | P56178 |
NCBI GenInfo Identifier: | 12644329 |
NCBI Gene ID: | 1749 |
NCBI Accession: | P56178.2 |
UniProt Secondary Accession: | P56178,Q9UPL1, B7Z4P3, |
UniProt Related Accession: | P56178 |
Molecular Weight: | 20,900 Da |
NCBI Full Name: | Homeobox protein DLX-5 |
NCBI Synonym Full Names: | distal-less homeobox 5 |
NCBI Official Symbol: | DLX5 |
NCBI Official Synonym Symbols: | SHFM1D |
NCBI Protein Information: | homeobox protein DLX-5 |
UniProt Protein Name: | Homeobox protein DLX-5 |
Protein Family: | Homeobox protein |
UniProt Gene Name: | DLX5 |
UniProt Entry Name: | DLX5_HUMAN |
Antibodies | ELISA Kits |
Anti-DLX5 Antibody (CAB15049) | DLX5 Transcription Factor Activity Assay |
DLX5 Antibody (PACO00711) | DLX5 Colorimetric Cell-Based ELISA |
DLX5 Antibody (PACO08861) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |